Healthy Joints, Healthy Heart
Risk
- OA patients have 24% increased risk of CVD 
- OA patients have 5 x risks of metabolic syndrome 
Pathology
- Vascular damage is linked to joint damage. 
- Joints are avascular 
- Blood flow to subchondral bone is compromised leading to ischaemia, affecting articular cartilage 
Obesity
- 10% weight loss = modest effect on pain 
- Similar to paracetamolol 
- 36% of knee replacements could be avoided if overweight and obesity were prevented 
- 20% could be avoided if overweight or obese people would move down one category of BMI